Abstract Views :184 |
Authors
Source
NIMHANS Journal, Vol 12, No 1 (1994), Pagination: 21-26
Abstract
Role of immunocytochemical localization of Herpes Simplex Viral antigen in cytological preparations viz., brain biopsy smears and CSF cytospin, for a rapid and specific diagnosis of the encephalitis was evaluated. The antigen could be localised in the neurons of the brain biopsy and mononuclear cells in CSF, in three cases, thus helping in a rapid diagnosis and timely antiviral treatment. Failure to localise the antigen in another brain biopsy alerted to seek alternative diagnosis and avoid the expensive Acyclovir therapy. Immunocytochemical detection of HSV antigen in cytological preparations appears to be a very useful technique for diagnosis in neurological practice.
Keywords
Herpes Simplex Encephalitis, Rapid Diagnosis, Cytological Preparations, Immunohistochemistry
